C. Difficile Toxin A thiab B thiab GDH Combo Test

C. difficile Toxin A thiab B thiab GDH Combo Test (Feces) yog qhov ceev chromatographic immunoassay rau kev tshawb nrhiav ib txhij ntawm Clostridium difficile Toxin A, Toxin B thiab glutamate dehydrogenase (GDH) antigen hauv tib neeg quav.

Xa kev nug

Hauj lwm lawm

Npaj siv

C. difficile Toxin A thiab B thiab GDH Combo Test muaj ib qho kev ntsuam xyuas yooj yim thiab muaj txiaj ntsig zoo los ua qhov kev kuaj pom tus kab mob Clostridium difficile.

Taw qhia

C. difficile yog gram-positive, spore-forming anaerobic bacillus. Toxigenic strains ntawm C. difficile tsim ob yam co toxins uas yog qhov tseem ceeb virulence yam tseem ceeb rau C. difficile kab mob (CDI). CDI raug suav hais tias yog lub luag haujlwm rau kwv yees li 25 feem pua ntawm cov kab mob raws plab uas cuam tshuam nrog kev noj tshuaj tua kab mob, thiab CDI tuaj yeem ua rau pseudomembranous colitis (PMC), xav tau kev kho mob sai nrog cov tshuaj tua kab mob uas muaj txiaj ntsig zoo rau C. difficile thiab uas, tsis muaj kev kho mob, yuav ua rau muaj kev cuam tshuam loj heev. lub neej ntawm cov neeg mob. Nyob rau hauv rooj plaub ntawm PMC, CDI kev tuag tuaj yeem siab li 6 feem pua rau 30 feem pua 1,2.

Kab mob vim C. difficile tshwm sim thaum cov kab mob tso cai rau proliferate nyob rau hauv txoj hnyuv, feem ntau tom qab siv tshuaj tua kab mob tau tshem tawm cov sib tw flora. C. difficile tuaj yeem tso ob lub siab molecular-yuag co toxins, co toxins A thiab toxin B, uas yog lub luag haujlwm rau kev kho mob tshwm sim, uas muaj xws li mob me, nws tus kheej txwv dej raws plab mus rau fulminant pseudomembranous colitis, lom megacolon, thiab tuag. Clostridium difficile Glutamate Dehydrogenase (GDH) yog ib qho enzyme uas tsim los ntawm ntau ntau los ntawm tag nrho cov kab mob toxigenic thiab non-toxigenic, ua rau nws yog ib qho cim zoo rau lub cev. Qhov txiaj ntsig zoo tshaj plaws ntawm GDH kev xeem yog lawv siv los ua ib qho screen los txiav txim cov qauv tsis zoo thiab xaiv cov qauv rau kev sim ntxiv.

Cov neeg asymptomatic tej zaum yuav yog cov neeg nqa khoom ntawm toxigenic C. difficile, ntawm cov uas, qee qhov yuav kis tau kab mob. Kev kuaj mob thiab kev sib txawv ntawm C. difficile toxin A thiab toxin B ua lub luag haujlwm tseem ceeb hais txog kev kho mob sai thiab kev tiv thaiv kab mob sib kis3.

Cov kev kuaj mob tam sim no ntawm CDI feem ntau yog kuaj pom cov kab mob, co toxins, lossis cov tshuaj lom neeg. Kev ceev immunoassay ntawm CDI tau dhau los ua qhov tseem ceeb dua vim tias muaj kev kuaj mob ncaj qha thiab kho tau zoo. Kev kuaj mob sai ntawm CDI tuaj yeem ua rau txo qis hauv tsev kho mob thiab cov nqi kho mob hauv tsev kho mob.

Cov txheej txheem xeem